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| The influence of postoperative analgesia by dexmedetomidine combined with sufentanil on sleep quality and serum brain-derived neurotrophic factor level of women undergone ovarian cancer surgery |
| Kaifeng Central Hospital, Henan Province,475000 |
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Abstract Objective: To analyze the influence of postoperative analgesia by dexmedetomidine combined with sufentanil on sleep quality and serum brain-derived neurotrophic factor (BDNF) of women undergone ovarian cancer surgery level in patients undergoing ovarian cancer surgery. Methods: From May 2015 to September 2018, 95 women with ovarian cancer who wanted to elective radical operation of ovarian cancer were randomly divided into observation group and control group. The women in the two groups were given the same intraoperative anesthesia, and 48 women in the observation group were given sufentanil combined with tropisetron and dexmedetomidine for postoperative analgesia, while 47 women in the control group were given sufentanil combined with tropisetron for postoperative analgesia. Visual Analogue Scale (VAS) and RSS sedation score were used to evaluate the pain degree and sedation effect. The subjective sleep quality of all women were monitored on one night before operation (T1), the night after operation (T2), and the next night after operation (T3). The level of serum BDNF of women before and after operation was measured by ELISA. The cumulative dosage of sufentanil and its adverse reactions were recorded 24 hours after surgery. Results: VAS scores of women in the observation group 6h, 12h, 24h and 48h after surgery were significant lower than those of women in the control group, and RSS scores of women in the observation group 1h and 6h after surgery were significant lower (P<0.05). There was no significant different in RSS scores of women 12h, 24h and 48h after surgery between the two groups (P>0.05). Compared with that at T1, the women in the both groups at T2 and T3 had significant longer sleep time, had significant lower sleep efficiency and autonomic sleep quality score. In addition, the women in the observation group had significant shorter sleep time, higher sleep efficiency, and higher autonomic sleep quality score than those of women in the control group, (P<0.05). The serum BDNF level of women in the two groups had decreased significantly 12h, 48h and 72h after operation, which of women in the observation group was significant lower than that of women in the control group (P<0.05). The serum BDNF level of women was negatively correlated with the autonomic sleep quality score (r=-0.582, P=0.037). The cumulative dosage of sufentanil and the incidence of adverse reactions of women in the observation group 24 hours after surgery were significant lower than those of women in the control group (P<0.05). Conclusion: Dexmedetomidine combined with sufentanil can more effectively improve postoperative sleep quality and reduce serum BDNF level of patients with ovarian cancer, which is better than sufentanil used alone.
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