Objective: To analyze the efficacy evaluation of low-dose aspirin combined with calcium and vitamin E for treating pregnant women with hypertensive disorder complicating pregnancy, and to study its influence on their serum levels of uric acid (UA) and Cystatin C (CysC). Methods: 160 pregnant women with hypertensive disorder complicating pregnancy were included and were divided into the control group (n=89) and observation group (n=71) according to random number table method from January 2016 to June 2018. The women in the control group were treated with magnesium sulfate, and the women in the observation group were treated with low-dose aspirin combined with calcium and vitamin E. The clinical curative effect, blood pressure, serum levels of calcium, UA, and CysC before and after treatment, and the pregnancy outcomes of women were compared between the two groups. Results: The total effective rate of women in the observation group was 93.0%, which was significant higher than that (81.0%) of women in the control group (P<0.05). After treatment, the values of diastolic blood pressure and systolic blood pressure, and the serum UA and CysC levels of women in the two groups had decreased significantly, and which decreased degree of women in the observation group was significant higher than that of women in the control group. After treatment, the serum calcium level of women in the two groups had increased significantly, and which increased degree of women in the observation group was significant higher than that of women in the control group (P<0.05). The incidences of premature delivery, cesarean section, postpartum hemorrhage, and fetal growth restriction of women in the observation group were 1.4%, 29.6%, 2.8%, and 1.4%,respectively, which were significant lower than those of women in the control group (P<0.05). Conclusion: Low-dose aspirin combined with calcium and vitamin E for treating pregnant women with hypertensive disorder complicating pregnancy can improve their pregnancy outcomes by improving the
effect of blood pressure controlled and decreasing the serum levels of UA and CysC of women.