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| The influence of laparoscopy on levels of sex hormones and neuroendocrine hormones, and pain stress indexes of patients with benign ovarian tumors#br# |
| The First people’s Hospital of Huai'an Affiliated To Nanjing Medical University, Jiangsu Province, 223300 |
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Abstract Objective: To explore the influence of laparoscopy on levels of sex hormones and neuroendocrine hormones, and pain stress indexes of patients with benign ovarian tumors. Methods: The data of 96 patients with benign ovarian tumors from January 2017 to June 2018 were retrospective analyzed. The included women were divided into in observation group and control group (48 cases in each group). Patients in the control group had undergone routine surgery, and patients in the observation group had undergone laparoscopic surgery. The levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), adrenocorticotropic hormone (ACTH), cortisol (COR), β-endorphin (β-EP), substance P (SP), interleukin-6 (IL-6) and prostaglandin-E2 (PGE2)of patients were compared between the two groups. Results: 1 month or 3 months after operation, the levels of FSH and LH of patients in both groups had increased significantly, and those of women in the control group were significant higher than those of patients in the observation group (P<0.05). 1 month or 3 months after operation, the levels of E2 and P patients in both groups had decreased significantly, and those of women in the control group were significant lower than those of patients in the observation group (P<0.05). The levels of ACTH, COR and β-EP of patients in the control group had increased significantly1 month after operation and 3 months after operation. The levels of ACTH, COR and β-EP of patients in the observation group had increased significantly 1 month after operation, but those of patients had no changed 3 month after operation (P>0.05). 3 months after operation, the levels of ACTH, COR and β-EP of patients in the control group were significant lower than those of patients in the observation group (P<0.05). The levels of SP, IL6 and PGE2 of patients in both groups had increased significantly after operation, and those of women in the observation group were significant lower than those of patients in the control group (P<0.05). Conclusion: Laparoscopic surgery has fewer side effects on the levels of sex hormones and neuroendocrine hormones, and pain stress indexes of patients with benign ovarian tumors.
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