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| The expressions of miR-16 and miR-182 in peripheral blood of women with somatoform disorder, and their relevant with the clinical features |
| 1.Mental Health Center Affiliated to Tongji Medical College of Huazhong University of Science and Technology, 430012；2. School of Medicine, Wuhan University of Science and Technology |
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Abstract Objective: To investigate the expressions of miR-16 and miR-182 in peripheral blood of women with somatoform disorder (SFD), and to study the relationships between the miR-16 and miR-182 levels and the clinical features. Methods: 115 women with SFD were selected into the study group from March 2017 to December 2018, and 118 health women were selected in the control group during the same period. Real-time fluorescence quantitative polymerase chain reaction (qRTPCR) was used to detect the expression levels of miR-16 and miR-182 in plasma of women in both groups. The relationships between the expressions of miR-16 and miR-182 in peripheral blood plasma of women with SFD and their clinical characteristics were analyzed. The symptom checklist 90 (SCL-90) was used for evaluated all women, and the risk factors of SFD were analyzed. Results: The expression levels of miR-16 and miR-182 in peripheral blood of women in the study group were 1.57±0.38 and 1.70±0.41, which were significant higher than those (1.02±0.30 and 1.09±0.33) of women in the control group (P<0.05). The relative expression levels of miR-16 and miR-182 in peripheral blood plasma of women with SFD were correlated with depression and anxiety factors (P<0.05). The average score of SCL-90 of women in the study group was 2.84±0.65 points, which was significant higher than that (1.72±0.39 points) of women in the control group (P<0.05). The relative expression levels of miR-16 and miR-182 were positively correlated with the mean score of SCL-90 (P<0.05). The levels of miR-16, miR-182 and SCL-90 score were all risk factors of SFD (P<0.05). Conclusion: The expressions of miR-16 and miR-182 in peripheral blood plasma of women with SFD are up-regulated, which are expected to be clinical indicators for diagnosing SFD.
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