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Abstract Objective: To analyze the effects of femoston and progynova for endometrial rehabilitation of patients with severe intrauterine adhesion after transcervical resection of adhesion (TCRA). Methods: 90 patients with severe intrauterine adhesion after TCRA were selected and were divided into the femoston group and the progynova group (45 cases in each group) according to the random number table. After surgical, the patients in femoston group were given femoston, and the patients in progynova group were given progynova. The uterine cavity morphology, menstrual recovery, uterine membrane status on ovulation day, adverse reactions rate, and pregnancy status of patients were compared between the two groups. Results: There was no statistically significant difference in postoperative uterine morphological recovery of patients between the two groups (P>0.05). The menstrual recovery efficiency of patients in femoston group was 84.4%, which was significantly higher than that (62.2%) of patients in progynova group (P<0.05). The intrauterine membrane thickness of patients on ovulation day in femoston group was 9.9±2.1mm, which was significant thicker than that(8.8±2.1mm) of patients in progynova group (P<0.05). The subendometrial blood flow parameters RI of patients in femoston group was 0.8±0.2, which was significant lower than that (0.9±0.1) of women in progynova group (P<0.05). There was no significant difference in endometrial classification subendometrial blood flow parameters (PI and S/D) of patients between the two groups (P>0.05). There was no significant difference in clinical pregnancy rate (55.6% vs.46.7%) of patients within 12 months after operation between the two groups (P>0.05). The average time from operation to pregnancy of patients in the femoston group was 5.3±2.7 mouths, which was significant shorter than that(7.0±3.3 mouths) of patients in progynova group (P<0.05), and there was no statistically significant difference in the incidence of adverse reactions of patients between the two groups (P>0.05). Conclusion: The femoston treating patients with severe intrauterine adhesion after TCRA can more effectively improve menstrual condition, increase the thickness of intrauterine membrane on ovulation day, and shorten the time from operation to pregnancy.
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