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| Effect of mifepristone combined with other different treatment for inducted labor of women during the first and second trimester pregnancy, and analysis of risk factors of related to curettage |
| Honghu People's Hospital, Honghu, Hubei Province,423200 |
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Abstract Objective: To explore the effects of different treatment for inducted labor of women during the first and second trimester pregnancy, and to analyze of risk factors of related to curettage. Methods: 168 pregnant women who wanted induction of labor during the first and second trimester pregnancy were enrolled in this study between July 2016 and December 2018. All included women were divided into 3 groups according to different treatment for inducted Labor.Women in group A were given ethacridine lactate combined with mifepristone (98 cases), women in group B were given misoprostol combined with mifepristone (40 cases), and women in group C were given water bag combined with mifepristone (30 cases). And all included women were further divided into curettage group (61 cases) and noncurettage group (107 cases).The duration of induced labor and the success rate of induction of labor, the rate of residual pregnancy, and curettage rate of women were compared among these groups. The multivariate twocategory logistic regression model was used to analyze the risk factors affecting curettage. Results: The gestational weeks of women in group B was significant less than that of women in group A and C (P<0.01), but there was no significant difference in gestational weeks of women between group A and group C (P>0.05). The duration of induced labor of women in group A was significant lower than that of women in group B and C (P<0.01), but there was no significant difference in duration of induced labor of women between groups B and C (P>0.05). The success rate of induced labor of women in group A was significant higher than that of women in group B and C (P<0.05), while there was no significant difference in the success rate of inducted labor of women between the group B and C (P>0.05). The residual of women in group A was significant higher than that of women in group B and C (P<0.05), but there was no significant difference in residual of women between group B and group C (P>0.05). The curettage rate of women in group B was significant higher than that of women in group A and C (P<0.05), but there was no significant difference in the curettage rate of women between group A and C (P>0.05).The logistic regression showed that the gestational weeks was the protective factor of curettage (P=0.004), and the residual after induced labor was the risk factor (P=0.033). Conclusion: Three treatments for induced labor have good success rate, and ethacridine lactate combined with mifepristone has the highest success rate. The risk of curettage after induced labor is closely related to the gestational weeks and the residual pregnancy. The best induced labor plan should be selected based on different characteristics of pregnant women, and effectively promote uterine contractions should be conducted for decreasing the occurrence of residual pregnancy.
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