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Abstract Objective: To investigate the relationship between pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) and of pregnant women with gestational diabetes mellitus (GDM) and the changes of glucose and lipid metabolism levels of these during pregnancy. Methods: From March 2015 to June 2017,120 women with GDM were included in group A, and 120 pregnant women with normal glucose tolerance (NGT) were included in group B. The women in group A were divided into emaciation group A 1 (BMI<18.5kg/m2, n=21), group A 2 (18.5kg/m2≤BMI<24.0 kg/m2, n=69), and group A 3(BMI≥24kg/m2, n=30) according to pre-pregnancy BMI. The women in group A were also divided into group Aa (less GWG, n=29), group Ab (appropriate GWG, n=55), and group Ac (excessive GWG, n=36) according to GWG of women during the third trimester pregnancy. The levels of glucolipid metabolic of women during the second and third trimester pregnancy in different groups were detected and compared. Results: The levels of FBG,PBG1,PBG2,FINS,HOMAIR,TC,TG,LDL-C and VLDL-C of women in group A were significant higher than those of women in group B (P<0.05),but there was no significant difference in TC level between group A and group B (P>0.05). In group A, the levels of FBG, PBG1, PBG2, FINS, HOMA-IR, TG, LDL-C and VLDL-C of women in group A 3 were significant higher than those of women in group A 1 and A 2 (P<0.05),there was no significant difference in TC level among group A 1, A 2 and A 3 (P>0.05). There were no significant differences in levels of glucolipid metabolic indicators of women during the second trimester pregnancy among group Aa, Ab, and Ac (P>0.05). During the third trimester pregnancy, the HDL-C level of women in group Ac was significant lower than that of women in group Aa or Ab, but the levels of FBG, PBG1, PBG2, FINS, HOMA-IR, TC, TG, LDL-C and VLDL-C of women in group Ac were significantly higher (P<0.05). Conclusion: High pre-pregnancy BMI or excessive GWG of pregnant women can aggravate the disorder of glycolipid metabolism during pregnancy, which is particularly serious in women with excessive GWG during the third trimester pregnancy.
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