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Abstract Objective: To compare the clinical effect of promoting ovulation between medroxyprogesterone acetate (MPA) used and gonadotropine (GnRH-a) long protocol used for treating women with frozen-thawed blastocysts transfer. Methods: The data of 617 treatment cycles of women with ovarian stimulation protocol were retrospective analyzed. The women were divided into group A (241 women treated by MPA combined with Gn protocol) and group B and (376 women treated by long GnRHa protocol). The parameters of ovulation induction of women were compared between the two groups. Results: The days of Gn used, the dosage of Gn used, the number of retrieved oocytes, the number of available embryos, the number of quality embryos, and the number of blastocysts of women in group A were 8.8±2.1d,2038.6±678.5 U,7.1±2.4 pieces, 3.9±1.1 piece, 3.1±1.2 piece, 3.9±1.1 piece, and 2.9±1.2 piece, respectively, which were significant higher than those （10.8±1.6d, 2276.4±854.6U, 12.1±2.5 piece, 5.4±1.9 piece, 4.4±1.9 piece, and 4.1±2.0 piece, respectively）of women in group B (P>0.05). Conclusion: Comparing to that of classical long protocol, MPA combined with Gn protocol has the similar implanting potential for frozen-thawed embryo transfer cycle, which can decrease the dosage of Gn significantly, so it can reduce the cost of treatment.
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