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Abstract Objective: To investigate the analgesia effects of nalbuphine hydrochloride injection for women after laparoscopic hysterectomy, and to study its effect on the levels of mean arterial pressure (MAP), heart rate (HR) and pulse oximetry (SpO2). Methods: Sixty women who had accepted laparoscopic hysterectomy under general anesthesia were enrolled and were divided into the study group and the control group by randomized digital table. The women in the study group were treated by nalbuphine 2.0 mg/kg, and the women in the control group were treated by sufentanil 100 μg intravenous analgesia. The changes of MAP, HR, SpO2 levels at different time points, visual analog pain score (VAS) before and after analgesia, Ramsay sedation score, and adverse reaction rate of women were compared between the two groups. Results: There were no significant different in the levels of HR, SpO2 and MAP of women before surgery and at 2h, 12h, 24h and 48h after surgery between the two groups (P<0.05). The VAS scores of women in the study group at 2h, 12h and 24h after surgery were significant lower than those of the control group (P<0.05), but those of women at 48h after surgery had no significant different between the two groups (P>0.05). Ramsay sedation score of women in the study group at 2h and 12h after surgery were significant lower than those of the control group (P<0.05), but those of women at 24h and 48h after surgery had no significant different between the two groups (P>0.05). The incidence of adverse reactions of women in the study group was 10.0%, which was significant lower than that (23.3%) of women in the control group (P<0.05). Conclusion: The analgesia effects of nalbuphine hydrochloride injection for women after laparoscopic hysterectomy is better than that of sufentanil used, which can keep hemodynamic fluctuations stable of women with less adverse reactions.
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