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Abstract Objective: To study the therapeutic effect of letrozole (LE) combined with human menopausal gonadotropin (HMG) for treating women with polycystic ovarian syndrome (PCOS). Method: 190 women with PCOS (410 treated cycles) were selected and divided randomly into the control group and the study group from August 2015 to March 2017. The women in the study group were treated by LE combined with HMG, and the women in the control group were treated by LE only. The therapeutic effect and adverse reaction rate of women in both groups were observed, and the sex hormone levels, endometrial thickness and cervical scoring of women were compared between the two groups. Results: The number of cycles with follicular diameter ≥16mm and clinical pregnancy rate of women in the study group were significant higher than those of women in the control group (P＜0.05), the improved rates of sex hormone levels, endometrial thickness and cervical scoring were significant better and adverse reaction rate was significant lower (P＜0.05). Conclusion: The LE combined with HMG has good therapeutic effect for women with PCOS, which can reduce the adverse reaction, adjust the sex hormone levels, and increase the pregnancy rate.
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