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Abstract Objective: To explore the relationship between endogenous estrogen level of postmenopausal women with parkinson's disease (PD) and their non-motor symptoms. Methods: 81 postmenopausal women with PD were selected in this study. The medical history data of all included women were collected. And the mental and motor abnormality of women were assessed by Parkinson's Disease Rating Scale (UPDRS), the motor function of women was evaluated by Hoehn and Yahr Scale (H&Y), the cognitive ability of women was assessed by Simple Mental State Examination Scale (MMSE), and the non-motor symptoms of women were assessed by Non-motor Symptoms Scale (NMSS). The correlation between E2 level and PD-related symptom score was analyzed. Results: The average E2 level of these women was (4.12±0.37) pg/ml. The NMSS score, components sleep/fatigue score, emotional score, sexual function score, and attention/memory of women with E2 level less than 4.12 pg/ml were 72.75±16.71 points,17.24±6.81, 18.24±7.24, 9.54±1.39,and 6.95± 1.72 points, respectively, which were significant higher than those (68.02±14.25 points, 14.02±4.16, 13.25±5.29, 6.02±1.34, and 4.31±0.62 points, respectively) of women with E2 level ≥4.12 pg/ml (P<0.05). The E2 level of all included women was negatively correlated to the NMSS score, sleep/fatigue score, and emotional score, but the correlation coefficient of women with E2 level <4.12 pg/ml was significant bigger than that of women with E2 level ≥4.12 pg/ml (r=-0.652, -0.512, -0.613 VS. r=-0.351, -0.421, -0.306, P<0.05). Conclusion: The endogenous estrogen level of postmenopausal women is associated with non-motor symptoms of postmenopausal women with PD, and the estrogen deficiency maybe the main cause of non-motor symptoms of postmenopausal women with PD.
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