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Abstract Objective: To observation of the efficacy and safety of four-dimensional ultrasound contrast-enhanced hysterosalpingography (4D-HyCoSy) for diagnosing tubal patency of infertility women. Methods: 80 infertility women were given tested by 4D-HyCoSy and X-ray hysterosalpingography (HSG) from August 2017 to December 2018. And the different diagnostic results of all women were confirmed by laparoscopic methylene blue (CLP). The diagnostic consistency between 4D-HyCoSy or HSG and CLP were evaluated, and the adverse reactions were recorded. Results: The sensitivity, specificity and accuracy of 4D-HyCoSy were 98.3%, 90.5% and 96.3%, respectively, and the sensitivity, specificity and accuracy of HSG were 89.8%, 95.2% and 91.3%, respectively. The Kappa value consistency between 4D-HyCoSy and CLP was 0.902, which was higher than that (0.790) between HSG and CLP. The rate of women with grade II and III pain response by 4D-HyCoSy tested was 7.5%, which was significant lower than that (23.8%) of HSG (χ2=8.012,P=0.005). The rate of genital tract bleeding (26.3%) by 4D-HyCoSy tested was significant lower than that (42.5%) by HSG tested (χ2=4.682, P=0.030). The time of genital tract bleeding by 4D-HyCoSy tested was (1.12±0.24)d, which was significantly shorter than that ［(1.79±0.37)d］ by HSG tested (t=4.193, P=0.000). Conclusion: Compared with HSG tested, 4D-HyCoSy tested for diagnosing tubal patency of infertility women has high consistent, good efficacy, and high safety with less adverse reactions.
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