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| The level of plasma miR 340 of women with gestational diabetes mellitus and its relevant to insulin resistance |
| Zhengzhou Maternal and Child Health Care Hospital, Henan Province, 450000 |
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Abstract Objective: To investigate the relationship between plasma miR 340 level of women with gestational diabetes mellitus (GDM) and their insulin resistance. Methods: 116 pregnant women were selected in this study as subjects, and were divided into group A (56 cases women with GDM) and group B (60 cases without GDM)from February 2016 to December 2017. The women in group A were further divided group A1 (30 women with insulin resistance, HOMA IR≥1.66) and group A2 (26 women, HOMA IR<1.66). Real time PCR (RT-PCR) technology was used to monitoring plasma miR 340 level. The insulin resistance index (HOMA IR) was calculated by steady state effect model. The plasma miR 340 level of women in the three groups were analyzed and their correlation to HOMA IR value was evaluated. Results: The plasma miR 340 level of women in group A was 0.61±0.09, and which was significant higher than that(0.10±0.02) of women in group B. The plasma miR 340 level of women in group A1 was 0.91±0.12, and which was significant higher than that(0.25±0.06) of women in group A2 (P<0.05). The plasma miR 340 expression of women in group A1 was positively correlated to the values of FPG and HOMA IR (r=0.324, 0.503, P<0.05), but was negatively correlated to the values of FINS and HOMA IS (r= 0.136, 0.302, P<0.05). Conclusion: The expression of plasma miR 340 of women with GDM increases significantly, and it is increasing following the insulin resistance becomes severe, so it can be used as an effective indicator for diagnosis and treatment of women with GDM.
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