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| The correlation of the expressions of serum SHBG, NF k 65, and Sfrp 5 of pregnant women to their gestational diabetes mellitus occurrence |
| 1.Oingdao Municipal Hospital，Shandong Province，266011; 2. The Ninth People's Hospital of Qingdao |
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Abstract Objective: To study the correlation of the expressions of serum neutral hormone binding globulin (SHBG), human nuclear transcription factor p65 (NF k Bp65) 65, and crimp related protein 5 (Sfrp 5) of pregnant women to their gestational diabetes mellitus (GDM) occurrence. Methods: 100 women with GDM were selected in the observation group from February 2014 to February 2017, and 80 normal pregnant women were in the control group during the same period. The serum levels of SHBG, NF k Bp65 and Sfrp 5 of all included women were detected. Results: The blood glucose level of women in the observation group was significant higher than that of women in the control group at 30 minutes, 1 hour and 2 hours after meal, and the insulin level was significant lower than that of women in the control group at 30 minutes and 2 hours after meal (P<0.05). The serum levels of SHBG and Sfrp 5 of women in the observation group were significant lower than those of women in the control group, but the level of NF k Bp65 was significant higher than that of women in the control group (P<0.05). The correlation analysis showed that levels of SHBG and Sfrp 5 were negatively correlated to the blood glucose and insulin levels, while level of NF k Bp65 was positively correlated to the blood glucose and insulin levels (P<0.05). Conclusion: The expression of SHBG, NF k Bp65 and Sfrp 5 of pregnant women is closely related to their occurrence of GDM, and it also provides new evidence for therapy of GDM by btargeted drug.
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