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Abstract Objective: To investigate the value of serum HCG (human chorionic gonadotropin), E2 (estradiol 2), P (progesterone) and CA125 (cancer-associated glycogen 125) levels of women during the first trimester pregnancy for diagnosing ectopic pregnancy or threatened abortion. Methods: The data of 160 women during the first trimester pregnancy were analyzed retrospectively, which included 48 cases with threatened abortion (threatened group), 32 cases with ectopic pregnancy (ectopic group), and 80 normal pregnant women (normal group). The serum levels of beta HCG, E2, P and CA125 of all women were detected, and their value for diagnosing ectopic pregnancy or threatened abortion was analyzed. Results: Among the three groups, the serum P, E2, and beta HCG levels of women in normal group were the highest and CA125 level was the lowest in ectopic group, but the serum P, E2, and beta HCG levels of women in ectopic group were the lowest of pregnant women and CA125 level was the highest in normal group (P<0.05). The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of combinative detection of serum levels of CA125, P, E2and beta HCG for the diagnosing ectopic pregnancy were which were 90.9%, 98.4%, 96.9%, 93.8% and 97.7%, respectively, which were significant higher than those of single detection of serum CA125 level, P level, E2 level or beta HCG level (P<0.05). Conclusion: During the first trimester pregnancy, there are significant different in the levels of serum beta HCG, E2, P and CA125 between the women with threatened abortion and the women with ectopic pregnancy. The combinative detection of serum levels of CA125, P, E2 and beta HCG for differential diagnosing threatened abortion or ectopic pregnancy has higher value.
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