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Abstract Objective: To investigate the change of Th1/Th2 value of women with recurrent spontaneous abortion (RSA) detected by flow cytometry peripheral blood stimulation method. Methods: 310 women with RSA were included in group A, 220 women without history of spontaneous abortion were in group B, 140 pregnant women with RSA were in group C, and 102 normal pregnant women were group D. There were 19 pregnant women with missed abortion. The levels of Th1 cells (CD4+/IFNγ+) and Th2 cells (CD4+/IL 4+) of all included women were detected by flow cytometry peripheral blood stimulation method after peripheral blood PMA+Ion stimulation，and the value of Th1/Th2 was calculated. Results：The Th1 cells levels of women in group A and the group B were always in the dominant state, and the dominant had no deviation to Th2 cell, there was no significant different in the value of Th1/Th2 of women between group A and group B (P>0.05). The Th1 cells levels of women in group C and the group D were still in the dominant state, and the dominant had no deviation to Th2 cell, there was no significant different in the value of Th1/Th2 of women between group C and group D (P>0.05). The Th1 cells level of pregnant women with missed abortion was also in the dominant state, and the dominant had no deviation to Th2 cell. Conclusion：The Th1 cells level of women with RSA before or after pregnancy and of the pregnant women with missed abortion are always in the dominant state, and the dominant has never deviation to their Th2 cell.
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