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Abstract Objective: To investigate the clinical efficacy of Longlu pill for treating infertility of patients with oligoasthenospermia. Methods：130 patients with oligoasthenospermia were selected and divided into the treatment group (n=78) and the control group (n=52). Before conducted assisted reproductive, the patients in the treatment group were given 5 Longlu pills (twice one day) for 12 weeks while the patients in the control group were not given any medicine. The traditional Chinese medicine symptoms scores, semen volume, sperm concentration, and the percentage of progressively motile sperm of all patients at 4, 8, and 12 weeks after treatment were recorded, and the serum hormone level of all patients at 12 weeks after treatment were detected. Results：8 weeks after treatment, the cardinal symptoms scores and secondary symptoms scores of patients in the treatment group were 6.2±1.5 points and 4.0±1.2 points, which were significant lower than those (10.6±2.1 points and 7.0±2.7 points) of patients before treatment (P<0.05). 12 weeks after treatment, the semen volume of patients in the treatment group was 3.23±0.72ml, which was significant higher than that (2.14±1.41ml) of patients before treatment (P<0.05). 4 weeks after treatment, the sperm concentration and percentage of progressively motile sperm of patients in the treatment group were 18.16±5.56×106／ml and 24.78±9.72%, which were significant higher than those (12.35±4.48×106／ml and 19.63±7.05%) of patients before treatment (P<0.05). 12 weeks after treatment, the serum testosterone level of patients in the treatment group was 3.39±0.70ng/ml, which was significant lower than that (5.67±1.18 ng/ml) of patients before treatment (P<0.05). Conclusion：Longlu pill can improve the semen quality of patients with oligoasthenospermia without obvious side effect.
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