Abstract Objective: To explore the effect of carboprost tromethamine for preventing and treating postpartum hemorrhage of women with scarred uterus, and to study its influence on coagulation function. Methods: 78 pregnant women with scar uterus were selected and randomly divided into the observation group and the control group (39 cases in each group). For preventing and treating postpartum hemorrhage, the women in the control group were given oxytocin intravenous drip after delivery, and the women in the observation group were given oxytocin intravenous drip combined with carboprost tromethamine intramuscular injection. The postpartum hemorrhage situation, the duration of uterine contraction, and the descending speed of uterine fundus, fibrinogen (FIB) level, platelet count, and the rate of adverse reaction of women were compared between the two groups. Results: The volume of blood loss during operation, the volume of blood loss in 2 hours after operation, the volume of blood loss in 24 hours after operation, and the duration of lochia of women in the observation group were (379.2±68.5) ml, (245.1±43.9) ml, (304.7±45.7) ml, (14.3±2.4) d, respectively, which were significant less than those of women in the control group (P<0.05). The postpartum hemorrhage rate of women in the observation group was 7.7%, which had no significant different from that of women in the control group (P>0.05). The duration of uterine contraction, the descending speed of uterine fundus, the platelet count of the observation group 24 hours, and the FIB level of women in the observation group were (3.2±1.1) h, (1.2±0.3) cm/d, (117.2±10.8)×109/L, (4.0±0.6) g/ml, respectively, which were significant higher than those of women in the control group (P<0.05). There were no significant different in the incidence of adverse reactions of women between the two groups (P>0.05). Conclusion: Carboprost tromethamine can reduce the rate and the volume of postpartum hemorrhage of women with scarred uterus by promoting the recovery of postpartum coagulation
function, and it has good safety.
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