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| Clinical effect of dydrogesterone combined with Gushenbaotai decoction for treating one child elderly pregnant women with the threatened abortion |
| Ma'anshan Traditional Chinese Medicine Hospital，Anhui Province, 243000 |
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Abstract Objective: To observe the effect of dydrogesterone combined with Gushenbaotai decoction for treating elderly pregnant women with the threatened abortion who had one child. Methods: 126 women with the threatened abortion who had one child were randomly divided into two groups (63 cases in each group). The women in group A were given low dose dydrogesterone only, and the women in group B were given dydrogesterone combined with Gushenbaotai decoction. The effects of tocolytic theraphy, immune function, adverse reactions rate, fetal development situation, and perinatal complications rate of women were compared between the two groups. Result: Compared with those of women before treatment, the levels of serum beta HCG, P and E2 of women in both groups increased significantly after treatment, and which of women in group B were significant higher than those of women in group A (P<0.05). The AcA positive rate of women in group B (0.0%) was significant lower than that (11.0%) of women in group A, but the BA positive rate of women in group B (55.6%) was significant higher than that (31.8%) of women in group A (P<0.05). The successful rate of tocolytic therapy of women in group B (95.2%) was significant higher than that (81.0%) of women in group A (P<0.05), and the remission time(31.8±5.3h) and disappearance time (78.8±8.4h) of symptoms of pregnant women in group B were significant shorter than those (37.2±5.5h and 87.2±10.3h) of women in group A (P<0.05). There were no significant different in the values of fetal NT and CRL of pregnant women during 12-14 gestational weeks between the two groups (P>0.05). Conclusion: Low dose of dydrogesterone combined with Gushenbaotai decoction can improve the effect of tocolytic therapy of pregnant women with the threatened abortion and has good safety, which can effectively improve the hormone levels by immune regulation.
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