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Abstract Objective: To investigate the effect of alfacalcidol combined with pioglitazone for treating women with polycystic ovary syndrome (PCOS), and to explore its influence on the insulin resistance of women. Methods: 86 women with PCOS patients were divided into two groups according to the random number table group. The women in the observation group were treated by alfacalciferol combined with pioglitazone, the women in the control group were treated by pioglitazone only. The situations of insulin resistance and ovulation, and sex hormones levels of women were compared between the two groups before and after treatment. The natural fertility rate of women in both groups was followed up. Results: The levels of FINS, FPG, 2hPG, and HOMA-IR, and the levels of E2, LH/FSH, T, LH, FAI, and FSH of women in both groups had decreased significantly after treatment (P<0.05), but HOMAβlevels of all women was significantly increased (P<0.05). The LH level of women in the observation group was significant lower than that of women in the control group (P<0.05), but there were no significant different in the levels of LH/FSH, T, LH, AI, and FSH of women between the two groups (P>0.05). The ovulation rate, the days ovulation promoted, and number of mature follicles after treatment of women in the observation group had no significant different from those of women in the control group (P>0.05). The pregnancy rate of women in the observation group was 55.8%, which had no significant different from that (44.2%) of women in the control group (P>0.05). Conclusion: Alfacalcidol combined with pioglitazone for treating women with PCOS can significantly alleviate the insulin resistance of women, and can regulate glucose metabolism disorders without influencing on sex hormone levels and ovulation status of women.
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