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| The preventing effect of Zishen qinggan huayu decoction combined with aspirin for preeclampsia occurrence of pregnant women |
| Hebi City People's Hospital, Henan Province, 458030 |
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Abstract Objective: To explore the preventing effect of Zishen qinggan huayu decoction combined with aspirin for preeclampsia occurrence of pregnant women. Methods: 106 pregnant women with high risk factors of pregnancy induced hypertension during less than 14 gestational weeks were selected as the subjects from August 2017 to February 2019，and were randomly divided into two groups (53 cases in each groups). The women in the experimental group were received Zishen qinggan huayu decoction combined with aspirin for preventing preeclampsia during pregnancy, while the women in the control group were given aspirin only. The TCM symptom score, the incidence of preeclampsia from 20 gestational weeks to delivery, the values of systolic blood pressure (SBP) and diastolic blood pressure (DBP), the level of 24 hour proteinuria, and pregnancy outcomes, and the rate of adverse reaction of all women in the two groups were observed. Results: In the experimental group, the incidences of mild and severe preeclampsia of women had no significant different between during 20-24 gestational weeks and during 25-28 gestational weeks (P>0.05). The incidences of mild preeclampsia and severe preeclampsia of women during 29-32 gestational weeks, 33-36 gestational weeks, and 37-40 gestational weeks in the experimental group were significant lower than those of women in the control group (P<0.05). There was no significant different in the vlues of SBP and DBP of women during 20-24 gestational weeks, 25-28 gestational weeks, and 29-32 gestational weeks between the two groups (P>0.05), but the values of SBP and DBP of women during 33-36 gestational weeks and 37-40 gestational weeks in the experimental group were significant lower than those of women in the control group (P<0.05). The 24 hour urinary protein level, and the incidences of neonatal asphyxia, placental premature and fetal growth retardation of women in the experimental group were significant lower than those of women in the control group, but the values of coagulation indexes of the women in the experimental group were significant higher (P<0.05). Conclusion: Zishen qinggan huayu decoction combined with aspirin can effectively prevent preeclampsia occurrence and improve pregnancy outcomes.
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