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| The relationship between the level of serum fat soluble vitamins or blood lipid of pregnant women and their occurrence of hypertensive disorder complicating pregnancy |
| The First People's Hospital of Xianning, Hubei Province, 437000 |
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Abstract Objective: To investigate the relationship between the level of serum fat soluble vitamins or blood lipid of pregnant women and their occurrence of hypertensive disorder complicating pregnancy (HDP). Methods: 102 pregnant women with HDP were selected into the observation group from May 2016 to May 2017, and other 75 healthy pregnant women were selected into the control group during the same period. The levels of serum fat soluble vitamin A(VA), vitamin E(VE), vitamin D(VD2 and VD3), serum triglyceride (TG), total cholesterol (TC), highdensity lipoprotein cholesterol (HLD), and low density lipoprotein cholesterol (LDL) of all included women were measured during 8-13+6 and 32-36 gestational weeks. The indicator relevant to perinatal infants were recorded. Results: During 8-13+6 gestational weeks, the serum levels of VA, TG and TC of women in the observation group were significant higher than those of women in the control group (P<0.05). The serum level of VA of women during 32-36 gestational weeks was significant lower than that of women during 8-13+6 gestational weeks, but the serum levels of VE, VD3, VD2, TG, TC, HDL, and LDL of women were significant higher than those of women (P<0.05).During 32-36 gestational weeks, the serum levels of TC, TG, LDL of normal pregnant women in the group, women with HDP, women with mild preeclampsia or with severe preeclampsia had increased gradually, while the VD3 and HDL levels decreased gradually (P<0.05). The delivery gestational weeks, neonatal birth weight, and placental weight of women in the observation group were all significant lower than those of women in the control group (P<0.05). Conclusion: The fat soluble vitamins and lipid metabolism levels of women will change during pregnancy. The deficiency of VD3 and HDC, and occurrence of hyperlipidemia of pregnant women are all involved in the pathogenesis of HDP. The serum lipid level of women during pregnancy should be monitored closely, which can predict the development of HDP and has some significance for early intervention and prognosis of HDP.
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