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Abstract Objective: To establish a public information network query system for China cord blood bank by using modern information technology, to improve the efficiency of umbilical cord blood HLA matching, to simplify the workflow of cord blood HLA matching, and to effectively utilize the public resources of cord blood in China. Method： An iterative and step-by-step approach to system construction had used for establishing this information system. This system was researched and designed based on the platform technology framework, business process and database, information exchange sharing, data security protection, subsystem functions, data management and analysis, which would realize the data of cord blood resources sharing and utilization between cord blood bank and medical institutions. Results：The main functions of the system included data collection service, HLA matching service, medical institution management, blood management of medical institutions, and blood distribution management of cord blood bank, and so on. By the end of 2018, the system had integrated all the effective data of 6 cord blood public banks and 85,644 cord blood data were connected by the internet, which had conducted trials in a number of medical institutions, and had searched and retrieved 230 matching data. Conclusion：The umbilical cord blood bank information network query system is an effective tool for clinical umbilical cord blood transplantation matching query, which has the characters of high efficient, fast and accurate.
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