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| Effect of Xinshenghua granules combined with mifepristone and misoprostol for treating women with missed abortion and its influence on serum HIF-1α and VEGF levels |
| 904 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Jiangsu Province,214000 |
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Abstract Objective: To explore the effect of Xinshenghua granules combined with tablets of mifepristone and misoprostol for treating women with missed abortion (MA), and to analyze its influence on serum levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF). Methods: 82 women with MA were enrolled, and were randomly divided into observation group and control group (41 cases in each group) from January 2017 to January 2018. The women in control group were treated by mifepristone and misoprostol tablets, and the women in observation group were treated by Xinshenghua granules combined with tablets of mifepristone and misoprostol. The efficacy rate and serum levels of HIF-1α and VEGF of women were compared between the two groups. Results: The complete abortion rate of women in observation group was 92.7%, which had no significant different from that (82.9%) of women in control group (P>0.05), but the time of embryo discharge and vaginal bleeding, and the volume of blood loss of women in observation group were significant less than those of women in control group (P<0.05). 1 and 2 weeks after treatment, the serum levels of HIF-1α and VEGF of all women were significant lower than those before treatment, and the serum levels of HIF-1α and VEGF of women in observation group were significant lower than those of women in control group (P<0.05). On the 7 day of treatment, the serum levels of HIF-1α and VEGF of women with vaginal bleeding stopped were significant lower than those of women with vaginal bleeding continually (P<0.05). In women with vaginal bleeding continually, the serum levels of HIF-1α and VEGF of women in observation group were significant lower than those of women in control group (P<0.05). There was no significant different in adverse reaction rate between the two groups (P>0.05). Conclusion: Xinshenghua granules combined with tablets of mifepristone and misoprostol for treating women with MA has the exact effect, which can promote embryo discharge, shorten the time of vaginal bleeding, and reduce the volume of vaginal bleeding. The mechanism may be related to the down regulation of serum HIF-1α and VEGF levels.
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