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Abstract To investigate the expression of fibroblast growth factor 21 (FGF 21) of pregnant women with subclinical hypothyroidism, and to study the relationship between FGF 21 level and dyslipidemia. Methods: From May 2014 to November 2017, 86 pregnant women with subclinical hypothyroidism were selected in study group, and 50 healthy pregnant women were selected in control group. The levels of Total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein A (Apo A), and apolipoprotein B (Apo B) were detected by Siemens ADVIA1800 automatic biochemical analyzer. The serum levels of TSH, FT4, FT3 and TPOAb were detected by chemiluminescence. The serum expression level of FGF-21 was measured by double antibody sandwich method. Pearson correlation analysis was used to analyze the relationship between FGF-21 level and dyslipidemia. Results: Serum TC and TG levels of women in study group (6.51±0.62) mmol/L, (2.52±0.73) mmol/L were significant higher than those (5.62±0.51) mmol/L, (1.85±0.95) mmol/L of women in control group, but LDL level of women in study group(4.26±0.69) mmol/L was significant lower than that (3.25±0.42) mmol/L] of women in control group(P<0.05). There was no significant different in levels of HDL, Apo A and Apo B between the two groups (P<0.05). Correlation analysis showed that FGF-21 level was positively correlated with the levels of TC and TG (r=0.419, 0.435, P<0.05), and negatively correlated with the LDL level (r=-0.406, -0.395, P<0.05), and had no correlated with the levels of HDL, Apo A, and Apo B (P>0.05). Conclusion: The levels of serum FGF-21 and lipids of pregnant women with hypothyroidism are significantly increased, and the level of serum FGF-21 is correlated with dyslipidemia.
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