|
Abstract To investigate the influence of regular intermittent epidural injection combined with dexmedetomidine on effect of labor analgesia and the levels of peripheral blood fibrinogen and D-dimer of postpartum women. Methods: 126 single pregnant women with full-term were selected as subjects from January 2016 to February 2018, and these women were divided into study group control group (63 cases in each group) by random number table method. The women in study group were treated by dexamethasone combined with regular intermittent epidural injection, and the women in control group were treated by regular intermittent epidural injection only. The analgesic afficacy of women in the two groups were evaluated, and the influence on the indicators of coagulation function ［such as prothrombin time (PT), partial activated thromboplastin time (APTT), thrombin time (TT), fibrinogen, and D-dimer］ were analyzed. Results: The effective time, onset time, maintenance time, the second stage and third stage time of labor of women in study group were significant shorter than those of women in control group (P<0.05), but the time of keeping analgesia and total analgesia were significant longer.The amount of extramembranous used of women in study group was significant less than that of women in control group (P<0.05). The PT, APTT and TT of women in study group were significant longer than those of women in control group (P<0.05), but the levels of FIB and D-D were significant lower than those of women in control group (P<0.05). There was no difference in the labor incubation period of women between the two groups (P>0.05). Conclusion: Dexmedetomidine combined with regular intermittent epidural injection intravenous injection can reduce rate of postpartum hypercoagulability, reduce the amount of epidural anesthetic drugs, shorten the labor time significantly, prolong analgesic time, and shorten the onset time, so it can be used in clinical practice.
|
|
|
|
|
|
