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| The humoral immune characteristics of pregnant women with viral hepatitis and its correlation with maternal and child outcomes |
| The Second People's Hospital of Jingzhou City, Hubei Province, 434000 |
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Abstract To investigate the humoral immune characteristics of pregnant women with viral hepatitis and its correlation with maternal and child outcomes. Methods: 130 pregnant women with viral hepatitis were included in observation group, and another 100 normal pregnant women were included in control group. The levels of serum immunoglobulin IgA, IgG, IgM, C3, C4 and total bile acid (TBA) of all included women were detected and compared between the two groups, and the correlation between humoral immune index and maternal and child outcomes were analyzed. Results: The IgM and TBA levels of pregnant women in observation group were significant higher than those of pregnant women in control group, but the IgG level of pregnant women in observation group was significant lower than that pregnant women in control group (P<0.05). There were no significant different in levels of IgA, C3, and C4 pregnant women between the two groups (P>0.05). TBA level was negatively correlated with IgM level, but positively correlated with IgG level (P<0.05).In observation group, there were significant different in the levels of IgM, IgG, and TBA of women with different Child-Pugh graders and different viral load (P<0.05). Following the Child-Pugh grade increased and the viral load increased, the levels of IgM and TBA of pregnant women gradually increased, and IgG level gradually decreased. The incidence of premature rupture of membranes, postpartum hemorrhage, miscarriage, premature birth, neonatal asphyxia, and fetal distress of pregnant women in observation group were significant higher than those of pregnant women in control group (P<0.05).There was no significant difference in the rate of abnormal humoral immunity of newborns between the two groups (P>0.05). Conclusion: The humoral immunity of pregnant women with viral hepatitis is generally impaired, and the degree of humoral immune dysfunction is closely related to maternal and neonatal outcomes. The more severe the impairment of humoral immunity, the worse the maternal and child outcomes.
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