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| The effect of different type chromosome polymorphismfrom of male on outcomes of conventional IVF |
| 1.The Fourth Affiliated Hospital of Hebei Medical University，Shijiazhuang，Hebei Province, 050011; 2. Hebei thoracic hospital |
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Abstract Objective:To investigate the effects of different types of chromosomal polymorphism of male on outcomes of conventional in vitro fertilization (IVF). Methods: A retrospective analysis was performed about patients undergone routine IVF AND karyotype analysis in the fourth hospital of Hebei medical university between June 2014 to June 2016. According to the chromosome polymorphism of male, the patients were divided into four groups: patients with D/G satellite increased in group A (n=21), patients with secondary constriction increases, which included 1, 9, and 16 chromosomes in group B (n=20), patients with pericentric inversion of chromosome 9 in group C (n=17), patients with big or small Y chromosome in group D (n=20), and patients with normal karyotype in group E (n=120). The semen parameters, situation of embryonic development, and pregnancy outcomes were compared among the groups. Results: There were no statistical significant different in semen volume, sperm concentration, percentage of sperm moving forward, rate of sperm viability, and rate of sperm normal morphology among the five groups (P>0.05). And There were also no statistically significant different in normal fertilization rate, total fertilization rate, good embryo rate, embryo implantation rate, clinical pregnancy rate, and early abortion rate among the five groups (P>0.05). Conclusion: The different types of male chromosome polymorphism has no any significant effect on outcomes of routine IVF.
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