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Abstract Objective:To explore the value of the soluble fms-like tyrosine kinase 1 (sFlt1), placenta growth factor (PlGF), the ratio of sFlt1 to PlGF (sFlt1/PlGF) and pulsatility index (PI) of the uterine artery doppler for predicting preeclampsia (PE). Methods: The study enrolled 527 pregnant women with high risk PE, and all women were divided into 4 groups based on blood pressure and urine protein. The correlation of the severity degree of the preeclampsia with different level of sFlt1 and PlGF, value of sFlt1/PlGF and PI were analyzed by the spearman correlation analysis. And that all included women were divided into normal group and pre-eclampsia group according to whether they had developed preeclampsia, and then ROC curve and logistic regression were done to explore the diagnostic value of level of sFlt and PlGF, and diagnose value of sFlt1/PlGF and PI for preeclampsia. Results: The level of sFlt 1 (r = 0.46, P < 0.01), PlGF (r = 0.36, P < 0.01), the value of sFlt 1/PlGF (r = 0.49, P < 0.49) and the value of PI (r =0.11, P < 0.05) had statistical correlation with the severity degree of preeclampsia. The level of sFlt 1 (t = 4.39, P < 0.01), the value of sFlt 1/PlGF (t = 93.17, P < 0.01), and the value of PI (t = 2.05, P = 0.042) of women in normal group were all significant less than those of women in preeclampsia group, but the level of PlGF (t = 4.63, P < 0.01) of women in normal group was significant more than that of women in preeclampsia group. The AUG of sFlt 1 was 0.68, the sensitivity was 63%, and specificity was 71%. The AUG of PlGF was 0.65, the sensitivity was 69%, and specificity was 58%.The AUG of SFlt 1/PlGF was 0.74, the sensitivity was 78%, and specificity was 69%. Logistic analysis showed that the model of PI combined with sFlt 1/PlGF had the highest value for predicting preeclampsia, which diagnosis efficiency was 84.3%. Conclusion: The value of SFlt 1/PlGF combined with PI can be applied to predict preeclampsia, which has high diagnosis efficiency and has high application value in clinical practice.
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