|
|
|
| Effect of carprost methyl ester suppository and misoprostol for treating postpartum hemorrhage and their influence on the serum levels of NO and NOS |
| The Seventh People's Hospital of Suzhou, Suzhou, Jiangsu Province |
|
|
|
|
Abstract Objective:To investigate the effect of carprost methyl ester suppository and misoprostol for treating postpartum hemorrhage of parturient after full term vaginal delivery, and to explore their influence on the levels of maternal serum nitric oxide synthase (NOS) and nitric oxide (NO). Methods: 108 parturients with full term vaginal delivery in the seventh people's hospital of Suzhou city were selected as study subjects from April 2017 to April 2018, and were divided into two groups according to the random number table method. 54 parturients in observation group were treated by carprost methyl ester suppository, and 54 parturients in control group were treated by misoprostol. The clinical efficacy of parturients was compared between the two groups. Serum NOS and NO levels of parturients were also compared between the two groups before and after treatment. The amount of vaginal bleeding at 2 and 24 hours postpartum, duration of uterus contractions or lochia, and incidence of adverse reactions of all parturients were recorded. Results: The perfect effective rate of parturients in observation group was 75.9%, which was significant higher than that (59.3%) of parturients in control group (P<0.05), but the total effective rate of parturients in observation group was 92.6%, which had no statistical significant different to that (83.3%) of parturients in control group (P>0.05). The serum levels of NOS and NO of parturients in observation group were significant lower than those of parturients in control group after treatment (P<0.05). The amount of vaginal bleeding of parturients at 2h and 24h postpartum in observation group was (321.15±24.25) ml and (124.15±13.85) ml, respectively, which were significant less than those (373.57±26.83) ml and (102.96±11.21) ml, respectively of parturients in control group (P<0.05). The duration of uterus contractions of parturients in observation group was significant longer than that of parturients in control group (P<0.05), and the duration of lochia of parturients in observation group was significant shorter than that of parturients in control group (P<0.05). The incidence of adverse reactions of parturients in observation group was 5.6%, which was not significant different from that (7.41%) of parturients in control group (P>0.05). Conclusion: Carboprost methyl ester suppository and misoprostol are effective for preventing postpartum hemorrhage of parturient with full term vaginal delivery. Except that, carboprost methyl ester suppository can reduce serum NOS and NO levels and can better reduce postpartum hemorrhage valume, and has better drug safety.
|
|
|
|
|
|
|
|
|
