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| The clinical value of serum CA125 combined with CA19-9 for assessing the illness state and postoperative recurrence of patients with endometriosis |
| Shiyan Taihe Hospital (Affiliated Hospital of Hubei Medical College), Shiyan, Hubei Province |
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Abstract Objective:To explore the clinical value of serum CA125 combined with CA19-9 for assessing the illness state and postoperative recurrence of patients with endometriosis. Methods: From January 2014 to February 2016, 104 patients with endometriosis in Shiyan taihe hospital of Hubei province were selected and divided into stage I group (31 cases), stage II group (31 cases), stage III group (41 cases), and stage IV group (28 cases) according to the illness state. At the same time, all included women also were divided into rehabilitation group (81 cases) and the recurrent group (19 cases) according to whether postoperative recurrence. Serum CA125 and CA19-9 levels of all patients were detected. Serum CA125 and CA19-9 levels and pain scores of patients in menstrual period were compared among the groups. ROC curve was used to evaluate the sensitivity of serum level of CA125 or CA19-9 for predicting recurrence of patients with endometriosis. Results: The serum levels of CA125 and CA19-9 of patients in stage I and II groups were signifficent lower than those of patients in stage III group (P<0.05), and the serum levels of CA125 and CA19-9 of patients in stage III group were signifficent lower than those of patients in stage IV group (P<0.05). There was a positive correlation between serum level CA125 and serum level CA19-9 (r=0.758, P<0.05). The serum levels of CA125 and CA19-9 of patients in recurrent group were significant higher than those of patients in rehabilitation group (P<0.05). ROC curve analysis had showed that the cutpoint of serum level of CA125 for predicting the endometriosis recurrent was 37.25 U/ml, and its sensitivity and specificity was 66.7% and 90.7%, respectively. And the cutpoint of serum level of serum CA19-9 for predicting the endometriosis recurrent was 40.5μg/ml, and its sensitivity and specificity were 37.5% and 95.3%, respectively. The sensitivity and specificity of serum level of CA125 combined with CA19-9 for predicting the endometriosis recurrence were 79.2% and 97.68%, respectively. Conclusion: Serum levels of
CA125 combined with CA19-9 is highly sensitive to assess the illness state and to predict postoperative recurrence of patients with endometriosis.
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