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| Effect of marvelon combined with metformin on procalcitonin, immune function and oxidative stress of patients with polycystic ovary syndrome |
| The Second People's Hospital of Jingzhou City, Jingzhou, Hubei Province |
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Abstract Objective: To observe the effect of marvelon combined with metformin on the levels of PCT, immune function and oxidative stress of patients with polycystic ovary syndrome (PCOS). Methods: 80 patients with PCOS who had been treated in the second people's hospital of Jingzhou city from June 2016 to June 2017 were included and divided into control group and observation group according to the random digital table method (40 cases in each group). The patients in control group were given marvelon treatment only, and the patients in observation group were given marvelon combined with metformin. The patients in the two groups were treated for 3 physiological cycles. The clinical efficacy of patients was compared between the two groups. The levels of serum T lymphocytes, PCT, MDA and SOD of patients in the two groups were detected before and after treatment. Results: The total effective rate of patients in control group was 67.5%, which was significant difference from that of patients (87.5%) in observation group (P<0.05). There was no significant different in the incidence of adverse reactions of patients between the two groups (P>0.05). Before treatment, there were no significant different in levels of serum T lymphocyte, PCT, MDA and SOD D3+, CD between the two groups (P>0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+ and SOD of patients in observation group had increased, which were significant higher than those of patients in control group, but the level of CD8+, PCT and MDA of patients in observation group were significant lower than those of patients in control group (P>0.05). Conclusion: Marvelon combined with metformin for treating patients with PCOS has good clinical effects. It can significantly improve the immune function of the patients, can relieve the state of inflammatory reaction, and can reduce the degree of oxidative stress in the body.
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