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Abstract Premature ovarian insufficiency (POI) is characterized by amenorrhea for 4-6 months with elevated gonadotropin levels affecting 1% of women before the age of 40 years. Although majority of cases are idiopathic, premature ovarian failure can be caused by genetic conditions, autoimmune disease, environmental factors, infectious agents, chemotherapy, and pelvic surgery. Members of the transforming growth factor- β (TGF- β) super family, which including TGFβs, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), inhibins, activins, follistatin and anti mullerian hormone (AMH). Via paracrine and/or autocrine mechanisms is involved in regulating follicular growth and development. Here, we review the studies which had reported genetically the genetic mutation of TGF β super family in POI patients.
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