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| Study of the influence of loop electrosurgical excision procedure on fertility of childbearing age women with cervical intraepithelial neoplasia |
| The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Inner Mongolia |
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Abstract Objective: To explore the influence of LEEP on fertility and pregnancy outcomes of childbearing age women with cervical intraepithelial neoplasia (CIN)．Methods: The data of 160 women who had experienced loop electrosurgical excision procedure (LEEP) because of CIN and had fertility requirements in first affiliated hospital of Peking university health science center from Feb. 2016 to Feb. 2018 were retrospective analyzed (in observation group). At that same period, another 210 healthy women with a birth plan in same hospital were selected into control group. Delivery mode, neonatal situation, and pregnancy outcomes were compared between the two groups. Results: The cesarean section rate caused by anthropogenic factors in observation group was significant higher than that in control group (P<0.05). There were no significant difference in abortion rate and the cesarean section rate without anthropogenic factors between the two groups (P>0.05). The incidences of premature delivery and premature rupture of membrane of women, and rate of lower weight newborn in observation group were significant higher than those of women in control group (P<0.05). The incidences of spontaneous abortion, premature rupture of membrane and rate of low weight of newborns of women with CIN III were significant higher than those of women with CINⅡor CINⅠ (P<0.05). As for women with period less than12 months from accepted LEEP to pregnancy, abortion rate and preterm birth rate were significant higher than those of women with period equal to or more than 12 months (P<0.05). There were no significant different in rate of cesarean delivery and rate of low weight of newborns (P>0.05). Conclusion: LEEP treating patients with CIN has no any adverse impact on late delivery way of patients, but maybe increase the incidence of premature, rupture of membrane, and low weight of newborns. Patients with CIN III have higher adverse pregnant outcomes when comparing that of patients with CIN I and CIN II. If patients have Longer time from accepted LEEP to pregnancy, the rates of spontaneous abortion and premature could decrease．
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