|
Abstract Objective: To investigate the effect of ethinyl estradiol cyproterone combined with pioglitazone for treating infertility patients with polycystic ovary syndrome (PCOS) and type 2 diabetes (T2DM). Methods: 88 infertility women with PCOS and T2DM were randomly divided into two groups.The women in research group (n=44) were treated by ethinyl estradiol cyproterone and pioglitazone for 3 months, the women in control group (n=44) were treated by ethinyl estradiol cyproterone and metformin for 3 months. The indexes of glucose and lipid metabolism, sex hormone before and after treatment were compared between the two groups. And the situation of menstrual cycle and ovulation, and rate of spontaneous conception were observed. Results: After treatment, the levels of BMI, WHR, LDLC, TC, TG, FBG, 2hPG, FINS, HbAlc and HOMAIR of women in research group were significantly lower than those of women in control group, while the levels of HDLC and HOMAβ were significantly higher (P<0.05).After treatment, the levels of E2, LH, FSH, LH / FSH, T, FAI and A2 of women in research group were significantly lower than those of women in control group, while SHBG were significantly higher (P<0.05).The follicles diameter of women in research group was significantly bigger than that of women in control group, while ovarian capsule thickness, ovarian volume and number of follicles were significantly lower (P<0.05). There was no significant difference in the incidence of ovarian hyper stimulation syndrome (OHSS) between the two groups (P>0.05), while the menstrual cycle normal rate, normal ovulation rate and pregnancy rate of women in research group were significantly higher than those of women in control group (P<0.05). Conclusion: Ethinyl estradiol cyprprovone combined with pioglitazone has exact effect for infertility women with PCOS and T2DM, which can decrease insulin resistance and androgen, and improve endocrine disorders, and can enhance the rate of natural conception.
|
|
|
|
|
|
