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Abstract Objective: To investigate the association between glucose 6phosphate dehydrogenase activity and body mass index of prepregnant reproductive age population. Methods: 86 341 males and 87 366 females who participated in the National Free Preconception Checkup Projects from 2013 to 2015 were enrolled as the study objects. Relevant information was collected by questionnaires, physical examinations and results of laboratory test. The baseline characteristics of G6PD activity were analyzed by chi square test, and multivariate Logistic regression models were used to estimate the influence of G6PD activity on the risk of BMI abnormalities (underweight, overweight or obesity). Results: The detection rates of low activity of G6PD in males and females were 3.8% and 1.9%, respectively. The incidences of males’ underweight, overweight or obesity were 4.9% and 37.9%, while those of female were 21.4% and 10.9%, respectively. Multivariate analysis results showed that compared with the G6PD normal objects, males with low activity of G6PD had higher risk of underweight (OR=1.32，95%CI=1.111.57 ) and lower risk of overweight or obesity (OR=0.84，95%CI=0.760.93 ) , while females with low activity of G6PD also had higher risk of underweight (OR=130，95%CI= 1.111.53 ), but the risk of overweight or obesity had not statistical significant diffrent. Conclusions: Low activity of G6PD can increase the risk of underweight among prepregnant reproductive age population. In order to reduce the risk of infertility and adverse pregnancy outcomes, it is necessary to strengthen weight management for prepregnant population with low activity of G6PD combined with underweight.
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WANG Long1, XIE Wenlu1, HUANG Jiaxin1, WU Siyu1, LIU Meiya1, LUI Youhong1, XU Die1, YANG Ying2, MA Xu2. A descriptive analysis of prepregnancy medication among Chinese women with pregnancy intention during 2013-2019[J]. 中国计划生育学杂志, 2024, 32(6): 1236-. |
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