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| Advances in treatment of Unexplained recurrent spontaneous abortion |
| Department of Gynecology and Obstetrics, Peking University First Hospital, Beijing 100034, China |
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Abstract Recurrent spontaneous abortion (RSA) has been contributed to various factors. Generally, etiological therapy can bring great pregnancy outcome to women with determined cause. However, it is hard to choose a specific clinical intervention for up to 40% cases that suffering with RSA, whose underlying cause have not yet been identified, named as unexplained recurrent spontaneous abortion (URSA). Therefore, how to bring benefit to those women is a big challenge in reproductive medicine. According to the hypothesis of the underlying etiology of URSA, the latest treatments can be divided into different aspects, including the intervention to abnormal chromosome and imbalanced alloimmunity, and empiric therapy. The theoretical foundations of different treatments and their feasibility as well as effectiveness evaluated by clinical studies can offer some guidance to future clinical treatment and study.
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