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| The influence of progesterone level of the HCG day on the pregnancy outcomes when in vitro fertilization embryo transfer |
| 1.Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052；2. Pingdingshan City Maternal and Child Health |
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Abstract Objective: To explore the influence of the progesterone level increased in the late follicular phase on pregnant outcomes when in vitro fertilization or intracytoplasmic sperm injection embryo transplantation (IVF/ICSIET) , to explore the relationship between the level of progesterone (P) increased and the number of retrieved oocytes and serum E2 levels on HCG day, and try to investigate the threshold value of the number of retrieved oocytes and the threshold value of HCG E2 when the progesterone concentration over 0.5 nmol/L in the late follicular phase. Methods: The clinical data of total 1517 patients with infertility treated by IVF/ICSIET in the third affiliated hospital of Zhengzhou university from January 1st 2008 to December 31st 2015 were selected in this study. All the patients were divided into three groups according to the serum progesterone level, which included low concentration group (P < 0.3nmol/L), middle concentration group (1 < p < 1.5 nmol/ml), and high concentration group (P > 1.5 nmol/ml). The general situation, medication, clinical characteristics and outcome of pregnancy were compared among the three groups. Results：The embryo implantation rate and the clinical pregnant rate of patients in high concentration group were statistically significant lower than those of patients in middle concentration group and low concentration group (P<0.05). The Gn dosage of patients in high concentration group was significant higher than that of patients in low concentration group and middle concentration group (P<0.05). There was no significant different in the high quality embryo formation rate among the three groups (P>0.05). The analysis of ROC curve showed that the least number of retrieved oocytes was 10.5 piece and E2 level was 11558.3pmol/L when P > 0.5nmol/L in the late follicular phase. The number of retrieved oocytes and E2 level had the positive correlation with the progesterone level increased. Conclusions: The progesterone level increased in the late follicular phase has no influence on quality of the embryos, but decreases the embryo implantation rate and the clinical pregnant rate. The number of retrieved oocytes and E2 level on the HCG day has the positive correlation.
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