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Abstract Objective: To study the risk of hypertension and metabolic disorders of postpartum women with gestational diabetes mellitus (GDM), and to explore the relevant factors leading to hypertension and metabolic disorders. Methods: From March 2014 to May 2016, 560 pregnant women who had completed system antenatal examination and given birth in the first people's hospital of huzhou city hospital were recruited into this study. All pregnant women were divided into GDM group or control group (NC group) according to whether diagnosed GDM during pregnancy. Age, body mass index (BMI), height, blood pressure, fasting plasma glucose (FPG), fasting insulin (FINS), glucose tolerance test (OGTT), total cholesterol (TCH), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG), free fatty acid (FFA), insulin resistance index (HOMAIR), and pancreatic βcell secretion (HBCI) of pregnant women were compared between the two groups or between prenatal and postpartum of women. Logistic regression was used to analyze the correlation of GDM leading to postpartum hypertension and metabolic disorders. Results: The level of FFA, TG, FPG, FINS, OGTT and HOMAIR of women in GDM group were significantly higher than those of women in control group, and the level of NC, HBCI and HDL of women in GDM group were significantly lower than those of women in NC group, but the level of TCH and LDL had no significant difference between the two groups. At postpartum one year, the level of systolic blood pressure, diastolic blood pressure, TG, LDL, OGTT and HOMAIR of women in GDM group were significantly higher than those of women in NC group, and the level of HDL of women was significantly lower than that of women in NC group, while the level of FFA, TCH, FPG, FINS and HBCI of women had no significant difference between the two groups. Conclusion: HBCI and HOMAIR are the correlation correlations of postpartum lipid metabolism abnormality, and BMI and HOMAIR are significant correlation factor of postpartum hypertension.
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