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Abstract Objective: To observe the clinical efficacy of low molecular weight heparin sodium combined with low dose progesterone for treating pregnant women with threatened abortion. Methods: 150 pregnant women with threatened abortion were randomly divided into study group and control group (75 cases in each group). The pregnant women in control group were treated by routine dose of progesterone, and the pregnant women in study group were treated by low doses of progesterone combined with low molecular heparin. Results: The time of bleeding stop, and time of abdominal and backache pain remission of women in study group were significantly shorter than those of women in control group, (P<0.05). The incidence of adverse effect of women (5.3%) in study group was significant lower than that of women (16%) in control group (P<0.05). Birth weight of newborn and gestational days before birth were significant greater than those of women in the control group (P<0.05). Malformation rate of newborn had no significant difference between the two groups (P>0.05). Conclusion: Compared to the conventional dose of progesterone treatment, low molecular weight heparin combined with low doses of progesterone can significantly reduce the bleeding time and abdominal pain relief time, can improve the therapeutic effectiveness for treating threatened abortion, can reduce rate of adverse effect of drugs, and has better safety and effectiveness of drugs.
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