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| Analysis of the influence of progesterone on maternal and infant outcomes when treating pregnant women with uterine fibroids |
| 1.Department of Gynaecology and Obstetrics，The Ninth Hospital of Wuhan City of Hubei Province, Hubei, 430081；2.Department of Gynaecology and Obstetrics，Hubei Province Wuhan City Maternal and Child Health Hospital |
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Abstract To investigate the influence of progesterone on maternal and child outcomes when treating pregnant women with uterine fibroids. Methods: Date of 92 pregnant women with uterine fibroids who came to the Ninth Hospital of Wuhan City of Hubei Province for tocolysis from Jan.2014 to Jan.2017 were retrospective analyzed. The included women were divided into treatment group (46 cases) and control group (46 cases) according to whether to used progesterone for tocolytic therapy. The progesterone levels, fibroids size before and after treated, incidence of red degeneration, rate of obstetric complications, and progesterone receptor expression of women in the two groups were compared. Results: There was no significant difference in progesterone level of women at first trimester between the two groups (P＞0.05), but progesterone level of women in treatment group at cesarean section time was significant higher than that of women in control group (P＜0.05). At cesarean section time, the sizes of fibroids of women in both groups was significant bigger than those of women at first trimester (P＜0.05), but there was no significant difference in sizes of fibroids of women at first trimester between the two groups (P＞0.05). The incidence of uterine fibroids red degeneration of women in treatment group was 60.9%, which had no statistical significant difference when compared to that of women(56.5%) in control group (P＞0.05). The total incidence of obstetric complications, Intraoperative blood loss, operative time, neonate apgar score and time of hospital stay of women between the two groups had no significant difference (P＞0.05). The positive rate of progesterone receptor of women in treatment group was 87.0%, which had no statistical significant difference when compared to that of women(80.7%) in control group (P＞0.05). Conclusion: When progesterone treating pregnant women with uterine fibroids for tocolysis, it has no side effect on uterine fibroids and complications of maternal and child, and it doesn’t increase the incidence of red degeneration of uterine fibroids.
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