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| Study of growth hormone used in different age patients with diminished ovarian reserve when undergone in vitro fertilization |
| Qinhuangdao Maternity and Child Health Care Hospital，Qinhuangdao，Hebei, 066000 |
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Abstract To investigate the influence on outcomes of different age women with diminished ovarian reserve（DOR）treated by growth hormone(GH) combined within GnRH antagonist protocol when undergone in vitro fertilization and embryo transfer（IVFET）. Methods：A total of 131 women with DOR were enrolled into this study，which included 69 women less than 35 years old and 62 women equal to or over 35 years old. All included women received the antagonist protocol. In order to observe the effect of GH on ovarian response and pregnancy outcome for different age women, women had used GH were in GH group, and women hadn’t used GH were in control group. Results：As for women with equal to or over 35 years old，the dosage of GH used of women in GH group was significantly lower than that of women in control group. Level of E2 and number of collected oocytes of women on the day of HCG administration had significantly increased compared to women in control group (P＜0.05). As for women less than 35 years old，there were no significant differences in clinical data and laboratory data. Conclusion：GH combine with a GnRH antagonist protocol could improve the ovarian response for equal to or over 35 years old women with diminished ovarian reserve，while there was no significant effect for women less than 35 years old.
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