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| Correlation analysis of level of homocysteine, folic acid or vitamin B12 and adverse pregnancy |
| Department of Obstetrics, Maternal and Child Health Hospital of Foshan City, Guangdong |
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Abstract To investigate the association of level of homocysteine, folic acid or vitamin B12 with adverse pregnancy. Methods: From October 2016 to March 2017, 70 pregnant women with adverse pregnancy outcomes were selected into group A, 627 pregnant women without adverse pregnancy outcomes were selected into group B, and 60 healthy childbearing women without pregnant were selected into control group. The level of serum homocysteine, folate and vitamin B12 were compared among the three groups. The correlation analysis of level of homocysteine, folic acid and vitamin B12 were examined by pearson correlation analysis. The risk factors of adverse pregnancy events were analyzed by non conditional Logistic multivariate regression analysis. Results: The level of homocysteine of women in group A was 11.19 ± 2.8 μmol/L, which was significantly higher than that of women in group B or control group. The level of folic acid and of vitamin B12 women in group A was 645.93 ± 281.36 nmol/L and 247.19 ± 102.2 pmol/L, which were significantly lower than those of women in group B and group C(P<0.05). Pearson correlation analysis showed that there was a negative correlation between the level of serum homocysteine and levels of folic acid and vitamin B12 (r=0.089, 0.108, P<0.05). Non conditional Logistic multivariate regression analysis showed that level of homocysteine elevated, level of vitamin B12 decreased and age of women increased were risk factors of adverse pregnancy (P<0.05). Conclusion: Level of Homocysteine elevated, level of vitamin B12 decreased and age of women increased are risk factors of adverse pregnancy. Clinical care and early intervention should be strengthened during pregnancy to prevent the occurrence of adverse pregnancy.
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