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Abstract Objective: To explore the effect of male chromosome polymorphism on ART. Methods: 3518 infertile couples asked for ART treatment for the first time were recruited in this study. The patients were divided into two groups according to the karyotype: the research group, 132 couples with chromosome polymorphism from male; the control group, 3386 couples with normal karyotype. Results: There were no statistically significant difference in the cleavage rate（65.5% VS. 67.9%）, high quality embryo rate（98.7% VS. 9.4%）, implantation rate（35.3% VS. 34.5%）, pregnancy rate（55.1% VS. 53.5%） and early miscarriage rate（9.8% VS. 8.9%） between the two groups (P＞0.05 ). But there was a higher po1ypronuclear rate in research group compared with control group among the patients undergoing ICSI-ET treatment (P＜0.05). Conclusion: Chromosome polymorphism from male may increase po1ypronuclear rate，but appears to have no adverse effects on the other outcomes of IVF/ICSI-ET, such as cleavage rate,implantation rate, clinical pregnancy rate and abortion rate.
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