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Abstract Objective: To explore the possible reasons for pregnant women with prenatal screening high-risk factors rejecting to seek further prenatal diagnosis. Methods: From January 2009 to December 2013, 393 pregnant women were recruited, who voluntarily did serological screening (trisomy 21 syndrome, neural tube defects, 18 trisomy edward syndrome) in Maternal and Child Care Service Centre of Xiaonan. Questionnaire was used to collect information on factors that could affect women willingness to seek further diagnosis. Results: In the 393 pregnant women with prenatal screening high-risk factors, only 176 women agreed to seek further prenatal diagnosis (44.78%), while 217 rejected to do that (55.22%). There were significant differences in age, education level, family income, cognition on screening results, understood of amniocentesis risk, and believed difficulty in seeking further prenatal diagnosis (P<0.001). Multi-variable logistic regression analysis showed that pregnant women with lower age (≤20 years) ,lower family income (≤ 5000 RMB per month) and believed more difficulty in seeking further diagnosis tended to refuse further prenatal diagnosis (ORs and 95% CI ,10.60, 2.89-38.96; 5.47, 2.35-12.73; 9.99, 3.66-27.28, respectively). Conclusions: Younger, lower income and believing more difficulty in seeking prenatal diagnosis were the possible factors that could affect pregnant women to seek further prenatal diagnosis.
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