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Abstract Objective: To explore the relationship of nuchal translucency thickness and fetal developmental abnormalities to provide references for clinical prenatal diagnosis. Methods: We collected the data of 1321 pregnancy women with a gestational age of 11 to 13+6 weeks and 45 to 84 mm of crown rump length who were measured the nuchal translucency thickness (NT) value by ultrasound and underwent a follow-up to 1 weeks postpartum in our hospital. We compared the NT value of different weeks of gestation and different maternal age, calculated the sensitivity, specificity, positive predictive value and negative predictive value of the diagnosis of fetal abnormalities. Results: There were 46 cases whose NT value was not less than 3.0 mm, of which 24 cases with dysplasia (3 cases of abnormal karyotypes, 21 cases of abnormal structure). Twenty-six cases of dysplasia were found, of which 24 cases with not less than 3.0 mm of NT value , and 2 cases with less than 3.0mm of NT value (1 case of abnormal karyotypes, 1 cases of abnormal structure). Compared NT value of different gestational age and different maternal age, we found that there were significant differences among groups of 11 to 11+6, 12 to 12+6, and 13 to 13+6 weeks of gestation (P<0.05), but there were no significant differences in groups of different maternal ages (P>0.05). We also found that when the NT value was greater than or equal to 3.0 mm, the sensitivity was 92.31%, the specificity was 98.30%, the positive predictive value was 52.17%, and the negative predictive value was 99.84%. Conclusion: Fetal NT value has close relationship with abnormal development of fetus in early pregnancy. Fetal NT value rises with the increase of gestational age, but has nothing to do with the maternal age. When the NT value is not less than 3.0mm, the sensitivity, specificity, positive predictive value and negative predictive value are most balanced. And fetal NT value can be used as an important index for early screening of fetal abnormalities.
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