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Abstract Objective: To compare the contraceptive efficacy of GyneFix/soft intrauterine device (IUD) with other common-using IUDs. Methods: We searched medical databases including CNKI (2008-2013), CBMdisc (2008-2013), Wanfang Database (2008-2013), VIP Database (2008-2013) by computer. And we screened randomized control trials and then performed the meta-analysis by using RevMan5.0 software. Results: Five articles from 177 literature were recruited for meta-analysis according to the inclusion and exclusion criteria. The rate of pregnancy with IUD in situ of GyneFix/soft IUD was lower than that of Yuangong copper 300 IUD when followed up at 12, 24 months ［Odd ratio (OR) were 0.06 and 0.09 respectively］. The expulsion rate of GyneFix/soft IUD was lower than that of Yuangong copper 300 IUD when followed up at 12, 24 months (OR were 0.19 and 0.17 respectively). The expulsion rate of GyneFix/soft IUD was lower than that of multiload copper 375 IUD when followed up at 12, 24 months (OR were 0.22 and 0.22 respectively). The removal rate for medical reasons of GyneFix/soft IUD was lower than those of cooper T380A IUD and Yuangong copper 300 IUD when followed up at 12, 24 months, and the differences were statistically significant. Conclusion: The rate of pregnancy with IUD in situ and the expulsion rate of GyneFix/soft IUD are low relatively. It has the favorable contraceptive efficacy and is worth using widely for less side effects and higher continuation rate.
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