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| Levels of the serum transforming growth factor-β1, interleukin-2 and matrix metalloproteinase-9 of women with tubal obstructive infertility and their clinical significance |
| The Second People's Hospital of Hengshui, Hengshui, Hebei Province, 053000 |
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Abstract To analyze the levels changes of the serum transforming growth factor-β1 (TGF-β1), interleukin-2 (IL-2) and matrix metalloproteinase-9 (MMP-9) of the women with tubal obstructive infertility, and to study their clinical significance. Methods: A total of 60 women with tubal obstructive infertility diagnosed and treated in the hospital were selected in study group and 50 women with normal pregnancy and delivery were selected in control group from March 2022 to October 2023. The serum TGF-β1, IL-2 and MMP-9 levels of the women were measured and compared between the two groups, and the correlation among which was analyzed by Pearson correlation analysis. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy of the serum TGF-β1, IL-2 and MMP-9 levels of the women for their infertility, and the influencing factors of the tubal obstructive infertility of the women were analyzed by logistic multivariate regression. Results: The preoperative levels of the serum TGF-β1 (593.79±148.23 ng/L), IL-2 (3.90±0.75 ng/L) and MMP-9 (384.88±86.87 ng/ml) of the women in the study group were significantly higher than those (239.42±113.37 ng/L, 3.09±0.84 ng/L and 178.98±80.85 ng/ml) of the women in the control group. The levels of the serum TGF-β1, IL-2 and MMP-9 of the women after surgery were significantly lower than those before surgery, the serum TGF-β1 level of the women was positively correlated with their serum IL-2 and MMP-9 levels, and the serum IL-2 level of the women was positively correlated with their serum MMP-9 level (all P<0.05). ROC curve analysis showed that the area under curve (AUC), the sensitivity and the specificity of the TGF-β1 level of the women for diagnosing their infertility were 0.941, 88.3% and 94.0%, respectively, which of the IL-2 level of the women for diagnosing their infertility were 0.778, 66.7% and 84.0%, respectively, which of the MMP-9 level of the women for diagnosing their infertility were0.946, 88.3% and 86.0%, respectively, and which of the combined levels of the serum TGF-β1, IL-2 and MMP-9 of the women for diagnosing their infertility were 0.992, 93.3% and 100.0%, respectively. Logistic regression analysis showed that the abnormal increasing serum TGF-β1, IL-2 and MMP-9 levels of the women were the risk factors of the infertility caused by fallopian tube obstruction of the women (all P<0.05). Conclusion: The levels of the serum TGF-β1, IL-2 and MMP-9 of the infertility women caused by fallopian tube obstruction are highly expressed, which are the risk factors of their infertility. The combined detections of the serum TGF-β1, IL-2 and MMP-9 of the women for diagnosing their infertility has high value for their tubal obstructive infertility.
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